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62-614: Fat is an oily or greasy organic substance. Fat or FAT may also refer to: Fat In nutrition , biology , and chemistry , fat usually means any ester of fatty acids , or a mixture of such compounds , most commonly those that occur in living beings or in food . The term often refers specifically to triglycerides (triple esters of glycerol ), that are the main components of vegetable oils and of fatty tissue in animals; or, even more narrowly, to triglycerides that are solid or semisolid at room temperature, thus excluding oils . The term may also be used more broadly as

124-416: A ketone ), the glycerol component of triglycerides can be converted into glucose , via gluconeogenesis by conversion into dihydroxyacetone phosphate and then into glyceraldehyde 3-phosphate , for brain fuel when it is broken down. Fat cells may also be broken down for that reason if the brain's needs ever outweigh the body's. Triglycerides cannot pass through cell membranes freely. Special enzymes on

186-422: A decreased risk of certain cancers, including breast and colorectal cancer, while other studies found no associations with cancer risk. Polyunsaturated fat supplementation was found to have no effect on the incidence of pregnancy-related disorders, such as hypertension or preeclampsia , but may increase the length of gestation slightly and decreased the incidence of early premature births. Expert panels in

248-507: A higher proportion of unsaturated acids, although there are exceptions such as coconut oil and palm kernel oil . Foods containing unsaturated fats include avocado , nuts , olive oils , and vegetable oils such as canola . Many scientific studies have found that replacing saturated fats with cis unsaturated fats in the diet reduces risk of cardiovascular diseases (CVDs), diabetes , or death. These studies prompted many medical organizations and public health departments, including

310-445: A highly palatable diet for several months. Analysis of their adipose tissue morphology revealed increases in both adipocyte size and number in most depots. Reintroduction of an ordinary chow diet to such animals precipitated a period of weight loss during which only mean adipocyte size returned to normal. Adipocyte number remained at the elevated level achieved during the period of weight gain. According to some reports and textbooks,

372-501: A large fraction of the population in developing countries. Concerns were also expressed at a 2010 conference of the American Dietetic Association that a blanket recommendation to avoid saturated fats could drive people to also reduce the amount of polyunsaturated fats, which may have health benefits, and/or replace fats by refined carbohydrates — which carry a high risk of obesity and heart disease. For these reasons,

434-405: A process called lipolysis . They are subsequently moved to absorptive enterocyte cells lining the intestines. The triglycerides are rebuilt in the enterocytes from their fragments and packaged together with cholesterol and proteins to form chylomicrons . These are excreted from the cells and collected by the lymph system and transported to the large vessels near the heart before being mixed into

496-423: A significant relationship between saturated fat and high serum cholesterol levels, which in turn have been claimed to have a causal relation with increased risk of cardiovascular disease (the so-called lipid hypothesis ). However, high cholesterol may be caused by many factors. Other indicators, such as high LDL/HDL ratio, have proved to be more predictive. In a study of myocardial infarction in 52 countries,

558-409: A single large lipid droplet surrounded by a layer of cytoplasm , and are known as unilocular. The nucleus is flattened and pushed to the periphery. A typical fat cell is 0.1 mm in diameter with some being twice that size, and others half that size. However, these numerical estimates of fat cell size depend largely on the measurement method and the location of the adipose tissue. The fat stored

620-506: A synonym of lipid —any substance of biological relevance, composed of carbon , hydrogen , or oxygen , that is insoluble in water but soluble in non-polar solvents . In this sense, besides the triglycerides, the term would include several other types of compounds like mono- and diglycerides , phospholipids (such as lecithin ), sterols (such as cholesterol ), waxes (such as beeswax ), and free fatty acids, which are usually present in human diet in smaller amounts. Fats are one of

682-503: A vital role in maintaining healthy skin and hair , insulating body organs against shock, maintaining body temperature, and promoting healthy cell function. Fat also serves as a useful buffer against a host of diseases. When a particular substance, whether chemical or biotic, reaches unsafe levels in the bloodstream, the body can effectively dilute—or at least maintain equilibrium of—the offending substances by storing it in new fat tissue. This helps to protect vital organs, until such time as

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744-466: A water molecule H 2 O . Other less common types of fats include diglycerides and monoglycerides , where the esterification is limited to two or just one of glycerol's –OH groups. Other alcohols, such as cetyl alcohol (predominant in spermaceti ), may replace glycerol. In the phospholipids , one of the fatty acids is replaced by phosphoric acid or a monoester thereof. The benefits and risks of various amounts and types of dietary fats have been

806-551: A weak atherogenic effect. Different saturated fatty acids have differing effects on various lipid levels. The evidence for a relation between saturated fat intake and cancer is significantly weaker, and there does not seem to be a clear medical consensus about it. Various animal studies have indicated that the intake of saturated fat has a negative effect on the mineral density of bones . One study suggested that men may be particularly vulnerable. Studies have shown that substituting monounsaturated fatty acids for saturated ones

868-448: Is a triglyceride , an ester of the triple alcohol glycerol H(–CHOH–) 3 H and three fatty acids. The molecule of a triglyceride can be described as resulting from a condensation reaction (specifically, esterification ) between each of glycerol's –OH groups and the HO– part of the carboxyl group HO(O=)C− of each fatty acid, forming an ester bridge −O−(O=)C− with elimination of

930-468: Is a transcription factor synthesized as an inactive precursor protein inserted into the endoplasmic reticulum (ER) membrane by two membrane-spanning helices . Also anchored in the ER membrane is SCAP (SREBF-cleavage activating protein), which binds SREBF1. The SREBF1-SCAP complex is retained in the ER membrane by INSIG1 (insulin-induced gene 1 protein). When sterol levels are depleted, INSIG1 releases SCAP and

992-741: Is about 75% monounsaturated fat. The high oleic variety sunflower oil contains at least 70% monounsaturated fat. Canola oil and cashews are both about 58% monounsaturated fat. Tallow (beef fat) is about 50% monounsaturated fat, and lard is about 40% monounsaturated fat. Other sources include hazelnut , avocado oil , macadamia nut oil , grapeseed oil , groundnut oil ( peanut oil ), sesame oil , corn oil , popcorn , whole grain wheat , cereal , oatmeal , almond oil , hemp oil , and tea-oil camellia . Polyunsaturated fatty acids can be found mostly in nuts, seeds, fish, seed oils, and oysters . Food sources of polyunsaturated fats include: MUFAs (especially oleic acid) have been found to lower

1054-459: Is associated with increased daily physical activity and resting energy expenditure. More physical activity, less anger, and less irritability were associated with a higher-oleic acid diet than one of a palmitic acid diet. The most common fatty acids in human diet are unsaturated or mono-unsaturated. Monounsaturated fats are found in animal flesh such as red meat , whole milk products, nuts, and high fat fruits such as olives and avocados. Olive oil

1116-618: Is beneficial for health. Consuming trans fats has been shown to increase the risk of coronary artery disease in part by raising levels of low-density lipoprotein (LDL, often termed "bad cholesterol"), lowering levels of high-density lipoprotein (HDL, often termed "good cholesterol"), increasing triglycerides in the bloodstream and promoting systemic inflammation. Adipocyte There are two types of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT), which are also known as white and brown fat, respectively, and comprise two types of fat cells. White fat cells contain

1178-603: Is contrary to the suggestion that polyunsaturated fats are shown to be protective against insulin resistance. The large scale KANWU study found that increasing MUFA and decreasing SFA intake could improve insulin sensitivity, but only when the overall fat intake of the diet was low. However, some MUFAs may promote insulin resistance (like the SFAs), whereas PUFAs may protect against it. Levels of oleic acid along with other MUFAs in red blood cell membranes were positively associated with breast cancer risk. The saturation index (SI) of

1240-456: Is in a semi-liquid state, and is composed primarily of triglycerides , and cholesteryl ester . White fat cells secrete many proteins acting as adipokines such as resistin , adiponectin , leptin and apelin . An average human adult has 30 billion fat cells with a weight of 30 lbs or 13.5 kg. If a child or adolescent gains sufficient excess weight, fat cells may increase in absolute number until age twenty-four. If an adult (who never

1302-433: Is not in the periphery of the cell. The brown color comes from the large quantity of mitochondria . Brown fat, also known as "baby fat," is used to generate heat. Marrow adipocytes are unilocular like white fat cells. The marrow adipose tissue depot is poorly understood in terms of its physiologic function and relevance to bone health. Marrow adipose tissue expands in states of low bone density but additionally expands in

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1364-521: Is partially modulated by dietary fat ratios ( omega−3 / 6 / 9 ) with both omega−3 and −9 thought to be anti-inflammatory, and omega−6 pro-inflammatory (as well as by numerous other dietary components, particularly polyphenols and exercise, with both of these anti-inflammatory). Although both pro- and anti-inflammatory types of fat are biologically necessary, fat dietary ratios in most US diets are skewed towards omega−6, with subsequent disinhibition of inflammation and potentiation of insulin resistance. This

1426-441: Is usually associated with obesity, the membrane phospholipids of the adipocytes of obese patients generally still show an increased degree of fatty acid unsaturation. This seems to point to an adaptive mechanism that allows the adipocyte to maintain its functionality, despite the increased storage demands associated with obesity and insulin resistance. A study conducted in 2013 found that, while INSIG1 and SREBF1 mRNA expression

1488-501: The ApoB / ApoA1 (related to LDL and HDL, respectively) ratio was the strongest predictor of CVD among all risk factors. There are other pathways involving obesity , triglyceride levels, insulin sensitivity , endothelial function , and thrombogenicity , among others, that play a role in CVD, although it seems, in the absence of an adverse blood lipid profile, the other known risk factors have only

1550-460: The Mediterranean Sea area, includes more total fat than the diet of Northern European countries, but most of it is in the form of unsaturated fatty acids (specifically, monounsaturated and omega-3) from olive oil and fish, vegetables, and certain meats like lamb, while consumption of saturated fat is minimal in comparison. A 2017 review found evidence that a Mediterranean-style diet could reduce

1612-469: The World Health Organization (WHO), to officially issue that advice. Some countries with such recommendations include: A 2004 review concluded that "no lower safe limit of specific saturated fatty acid intakes has been identified" and recommended that the influence of varying saturated fatty acid intakes against a background of different individual lifestyles and genetic backgrounds should be

1674-407: The circulation . These metabolic activities are regulated by several hormones (e.g., insulin , glucagon and epinephrine ). Adipose tissue also secretes the hormone leptin . A variety of chemical and physical techniques are used for the production and processing of fats, both industrially and in cottage or home settings. They include: The pancreatic lipase acts at the ester bond, hydrolyzing

1736-429: The fatty tissue of obese individuals, there is increased production of metabolism modulators, such as glycerol , hormones , macrophage -stimulating chemokines , and pro-inflammatory cytokines , leading to the development of insulin resistance . Production of these modulators and the resulting pathogenesis of insulin resistance are probably caused by adipocytes as well as immune system macrophages that infiltrate

1798-744: The rumen of these animals. CLA has two double bonds, one in the cis configuration and one in trans , which makes it simultaneously a cis - and a trans -fatty acid. Concerns about trans fatty acids in human diet were raised when they were found to be an unintentional byproduct of the partial hydrogenation of vegetable and fish oils. While these trans fatty acids (popularly called "trans fats") are edible, they have been implicated in many health problems. The hydrogenation process, invented and patented by Wilhelm Normann in 1902, made it possible to turn relatively cheap liquid fats such as whale or fish oil into more solid fats and to extend their shelf-life by preventing rancidification. (The source fat and

1860-855: The AHA estimated that replacement of saturated fat with polyunsaturated fat in the American diet could reduce the risk of cardiovascular diseases by 30%. The consumption of saturated fat is generally considered a risk factor for dyslipidemia —abnormal blood lipid levels, including high total cholesterol, high levels of triglycerides, high levels of low-density lipoprotein (LDL, "bad" cholesterol) or low levels of high-density lipoprotein (HDL, "good" cholesterol). These parameters in turn are believed to be risk indicators for some types of cardiovascular disease. These effects were observed in children too. Several meta-analyses (reviews and consolidations of multiple previously published experimental studies) have confirmed

1922-567: The SREBF1-SCAP complex can be sorted into transport vesicles coated by the coatomer COPII that are exported to the Golgi apparatus . In the Golgi apparatus, SREBF1 is cleaved and released as a transcriptionally active mature protein. It is then free to translocate to the nucleus and activate the expression of its target genes. Clinical studies have repeatedly shown that even though insulin resistance

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1984-571: The U.S. Food and Drug Administration , for example, recommends to consume at least 10% (7% for high-risk groups) of calories from saturated fat, with an average of 30% (or less) of total calories from all fat. A general 7% limit was recommended also by the American Heart Association (AHA) in 2006. The WHO/FAO report also recommended replacing fats so as to reduce the content of myristic and palmitic acids, specifically. The so-called Mediterranean diet , prevalent in many countries in

2046-716: The United States and Europe recommend that pregnant and lactating women consume higher amounts of polyunsaturated fats than the general population to enhance the DHA status of the fetus and newborn. In nature, unsaturated fatty acids generally have double bonds in cis configuration (with the adjacent C–C bonds on the same side) as opposed to trans . Nevertheless, trans fatty acids (TFAs) occur in small amounts in meat and milk of ruminants (such as cattle and sheep), typically 2–5% of total fat. Natural TFAs, which include conjugated linoleic acid (CLA) and vaccenic acid , originate in

2108-416: The adult cell is termed a lipoblast , and a tumor of this cell type is known as a lipoblastoma . Fat cells in some mice have been shown to drop in count due to fasting and other properties were observed when exposed to cold. If the adipocytes in the body reach their maximum capacity of fat, they may replicate to allow additional fat storage. Adult rats of various strains became obese when they were fed

2170-436: The blood. Various tissues can capture the chylomicrons, releasing the triglycerides to be used as a source of energy. Liver cells can synthesize and store triglycerides. When the body requires fatty acids as an energy source, the hormone glucagon signals the breakdown of the triglycerides by hormone-sensitive lipase to release free fatty acids. As the brain cannot utilize fatty acids as an energy source (unless converted to

2232-406: The bond and "releasing" the fatty acid. In triglyceride form, lipids cannot be absorbed by the duodenum . Fatty acids, monoglycerides (one glycerol, one fatty acid), and some diglycerides are absorbed by the duodenum, once the triglycerides have been broken down. In the intestine , following the secretion of lipases and bile , triglycerides are split into monoacylglycerol and free fatty acids in

2294-454: The course of experiment. Notably, there was no change in the size of the lower-body adipocytes. Approximately 10% of fat cells are renewed annually at all adult ages and levels of body mass index without a significant increase in the overall number of adipocytes in adulthood. Obesity is characterized by the expansion of fat mass, through adipocyte size increase ( hypertrophy ) and, to a lesser extent, cell proliferation ( hyperplasia ). In

2356-722: The fat it requires from other food ingredients, except for a few essential fatty acids that must be included in the diet. Dietary fats are also the carriers of some flavor and aroma ingredients and vitamins that are not water-soluble . In humans and many animals, fats serve both as energy sources and as stores for energy in excess of what the body needs immediately. Each gram of fat when burned or metabolized releases about nine food calories (37 kJ = 8.8 kcal ). Fats are also sources of essential fatty acids , an important dietary requirement. Vitamins A , D , E , and K are fat-soluble, meaning they can only be digested, absorbed, and transported in conjunction with fats. Fats play

2418-412: The fate determination of pre-adipocytes although the exact lineage of adipocyte is still unclear. The variation of body fat distribution resulting from normal growth is influenced by nutritional and hormonal status dependent on intrinsic differences in cells found in each adipose depot. Mesenchymal stem cells can differentiate into adipocytes, connective tissue , muscle or bone . The precursor of

2480-490: The focus in future studies. This advice is often oversimplified by labeling the two kinds of fats as bad fats and good fats , respectively. However, since the fats and oils in most natural and traditionally processed foods contain both unsaturated and saturated fatty acids, the complete exclusion of saturated fat is unrealistic and possibly unwise. For instance, some foods rich in saturated fat, such as coconut and palm oil, are an important source of cheap dietary calories for

2542-408: The incidence of insulin resistance ; PUFAs (especially large amounts of arachidonic acid ) and SFAs (such as arachidic acid ) increased it. These ratios can be indexed in the phospholipids of human skeletal muscle and in other tissues as well. This relationship between dietary fats and insulin resistance is presumed secondary to the relationship between insulin resistance and inflammation , which

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2604-498: The maintenance of active SREBF1 levels. This seems to help compensate for the anti-lipogenic effects of insulin resistance and thus preserve adipocyte fat storage abilities and availability of appropriate levels of fatty acid unsaturation in face of the nutritional pressures of obesity. Adipocytes can synthesize estrogens from androgens , potentially being the reason why being underweight or overweight are risk factors for infertility . Additionally, adipocytes are responsible for

2666-504: The merits of substituting polyunsaturated fats for saturated fats. The effect of saturated fat on cardiovascular disease has been extensively studied. The general consensus is that there is evidence of moderate-quality of a strong, consistent, and graded relationship between saturated fat intake, blood cholesterol levels, and the incidence of cardiovascular disease. The relationships are accepted as causal, including by many government and medical organizations. A 2017 review by

2728-534: The number of adipocytes can increase in childhood and adolescence, though the amount is usually constant in adults. Individuals who become obese as adults, rather than as adolescents, have no more adipocytes than they had before. People who have been fat since childhood generally have an inflated number of fat cells. People who become fat as adults may have no more fat cells than their lean peers, but their fat cells are larger. In general, people with an excess of fat cells find it harder to lose weight and keep it off than

2790-410: The number of fat cells can decrease if weight loss is maintained for a sufficiently long period of time (>1 year; though it is extremely difficult for people with larger and more numerous fat cells to maintain weight loss for that long a time). A large meta-analysis has shown that white adipose tissue cell size is dependent on measurement methods, adipose tissue depots, age, and body mass index; for

2852-411: The obese who simply have enlarged fat cells. Body fat cells have regional responses to the overfeeding that was studied in adult subjects. In the upper body, an increase of adipocyte size correlated with upper-body fat gain; however, the number of fat cells was not significantly changed. In contrast to the upper body fat cell response, the number of lower-body adipocytes did significantly increase during

2914-1054: The object of much study, and are still highly controversial topics. There are two essential fatty acids (EFAs) in human nutrition: alpha-Linolenic acid (an omega-3 fatty acid ) and linoleic acid (an omega-6 fatty acid ). The adult body can synthesize other lipids that it needs from these two. Different foods contain different amounts of fat with different proportions of saturated and unsaturated fatty acids. Some animal products, like beef and dairy products made with whole or reduced fat milk like yogurt , ice cream , cheese and butter have mostly saturated fatty acids (and some have significant contents of dietary cholesterol ). Other animal products, like pork , poultry , eggs , and seafood have mostly unsaturated fats. Industrialized baked goods may use fats with high unsaturated fat contents as well, especially those containing partially hydrogenated oils , and processed foods that are deep-fried in hydrogenated oil are high in saturated fat content. Plants and fish oil generally contain

2976-416: The observed health impact of replacing dietary saturated fat with linoleic acid found that it increased rates of death from all causes, coronary heart disease, and cardiovascular disease. These studies have been disputed by many scientists, and the consensus in the medical community is that saturated fat and cardiovascular disease are closely related. Still, these discordant studies fueled debate over

3038-508: The offending substances can be metabolized or removed from the body by such means as excretion , urination , accidental or intentional bloodletting , sebum excretion, and hair growth. In animals, adipose tissue , or fatty tissue is the body's means of storing metabolic energy over extended periods of time. Adipocytes (fat cells) store fat derived from the diet and from liver metabolism . Under energy stress these cells may degrade their stored fat to supply fatty acids and also glycerol to

3100-575: The pattern was reversed: the Hungarian product containing twice the trans fat of the New York product. Even within the United States, there was variation, with fries in New York containing 30% more trans fat than those from Atlanta . Numerous studies have found that consumption of TFAs increases risk of cardiovascular disease. The Harvard School of Public Health advises that replacing TFAs and saturated fats with cis monounsaturated and polyunsaturated fats

3162-432: The process were initially kept secret to avoid consumer distaste. ) This process was widely adopted by the food industry in the early 1900s; first for the production of margarine , a replacement for butter and shortening, and eventually for various other fats used in snack food, packaged baked goods, and deep fried products. Full hydrogenation of a fat or oil produces a fully saturated fat. However, hydrogenation generally

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3224-491: The risk of cardiovascular diseases, overall cancer incidence, neurodegenerative diseases, diabetes, and mortality rate. A 2018 review showed that a Mediterranean-like diet may improve overall health status, such as reduced risk of non-communicable diseases. It also may reduce the social and economic costs of diet-related illnesses. A small number of contemporary reviews have challenged this negative view of saturated fats. For example, an evaluation of evidence from 1966 to 1973 of

3286-446: The same degree of obesity, increases in fat cell size were also associated with the dysregulations in glucose and lipid metabolism. Brown fat cells are polyhedral in shape. Brown fat is derived from dermatomyocyte cells. Unlike white fat cells, these cells have considerable cytoplasm, with several lipid droplets scattered throughout, and are known as multilocular cells. The nucleus is round and, although eccentrically located, it

3348-532: The same membranes was inversely associated with breast cancer risk. MUFAs and low SI in erythrocyte membranes are predictors of postmenopausal breast cancer. Both of these variables depend on the activity of the enzyme delta-9 desaturase (Δ9-d). Results from observational clinical trials on PUFA intake and cancer have been inconsistent and vary by numerous factors of cancer incidence, including gender and genetic risk. Some studies have shown associations between higher intakes and/or blood levels of omega-3 PUFAs and

3410-442: The setting of obesity. Marrow adipose tissue response to exercise approximates that of white adipose tissue . Exercise reduces both adipocyte size as well as marrow adipose tissue volume, as quantified by MRI or μCT imaging of bone stained with the lipid binder osmium . Pre-adipocytes are undifferentiated fibroblasts that can be stimulated to form adipocytes. Studies have shed light into potential molecular mechanisms in

3472-463: The three main macronutrient groups in human diet , along with carbohydrates and proteins , and the main components of common food products like milk , butter , tallow , lard , salt pork , and cooking oils . They are a major and dense source of food energy for many animals and play important structural and metabolic functions in most living beings, including energy storage, waterproofing, and thermal insulation . The human body can produce

3534-439: The tissue. Fat production in adipocytes is strongly stimulated by insulin . By controlling the activity of the pyruvate dehydrogenase and the acetyl-CoA carboxylase enzymes, insulin promotes unsaturated fatty acid synthesis . It also promotes glucose uptake and induces SREBF1 , which activates the transcription of genes that stimulate lipogenesis . SREBF1 ( sterol regulatory element-binding transcription factor 1)

3596-946: The total fat in those foods containing man-made trans fats formed by partially hydrogenating plant fats may be trans fat. Baking shortenings, unless reformulated, contain around 30% trans fats compared to their total fats. High-fat dairy products such as butter contain about 4%. Margarines not reformulated to reduce trans fats may contain up to 15% trans fat by weight, but some reformulated ones are less than 1% trans fat. High levels of TFAs have been recorded in popular "fast food" meals. An analysis of samples of McDonald's French fries collected in 2004 and 2005 found that fries served in New York City contained twice as much trans fat as in Hungary , and 28 times as much as in Denmark , where trans fats are restricted. For Kentucky Fried Chicken products,

3658-632: The walls of blood vessels called lipoprotein lipases must break down triglycerides into free fatty acids and glycerol. Fatty acids can then be taken up by cells via fatty acid transport proteins (FATPs). Triglycerides, as major components of very-low-density lipoprotein (VLDL) and chylomicrons , play an important role in metabolism as energy sources and transporters of dietary fat. They contain more than twice as much energy (approximately 9   kcal/g or 38   kJ /g) as carbohydrates (approximately 4   kcal/g or 17   kJ/g). The most common type of fat, in human diet and most living beings,

3720-485: Was decreased in the adipose tissue of obese mice and humans, the amount of active SREBF1 was increased in comparison with normal mice and non-obese patients. This downregulation of INSIG1 expression combined with the increase of mature SREBF1 was also correlated with the maintenance of SREBF1-target gene expression. Hence, it appears that, by downregulating INSIG1, there is a resetting of the INSIG1/SREBF1 loop, allowing for

3782-781: Was interrupted before completion, to yield a fat product with specific melting point, hardness, and other properties. Partial hydrogenation turns some of the cis double bonds into trans bonds by an isomerization reaction . The trans configuration is favored because it is the lower energy form. This side reaction accounts for most of the trans fatty acids consumed today, by far. An analysis of some industrialized foods in 2006 found up to 30% "trans fats" in artificial shortening, 10% in breads and cake products, 8% in cookies and crackers, 4% in salty snacks, 7% in cake frostings and sweets, and 26% in margarine and other processed spreads. Another 2010 analysis however found only 0.2% of trans fats in margarine and other processed spreads. Up to 45% of

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3844-417: Was obese as a child or adolescent) gains excess weight, fat cells generally increase in size, not number, though there is some inconclusive evidence suggesting that the number of fat cells might also increase if the existing fat cells become large enough (as in particularly severe levels of obesity). The number of fat cells is difficult to decrease through dietary intervention, though some evidence suggests that

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